发明名称 |
MODULATION OF GAMMA-SECRETASE ACTIVITY |
摘要 |
<p>The present invention provides cell-free gamma-secretase activity. The method of the invention utilizes a membrane source of APP/gamma-secretase mixture in the assay to determine factors that may enhance or decrease enzymatic activity affecting beta-amyloid peptide production. The cell membranes used in the assay may be from cells expressing an endogenous APP or, preferably, cells expressing a recombinant APP. The APP may be full-length or a fragment capable of being proteolytically cleaved by gamma-secretase. In addition, the APP expressed in the cells may have one or more mutation, such as a point mutation, small deletion, etc.</p> |
申请公布号 |
EP1305406(B2) |
申请公布日期 |
2014.11.12 |
申请号 |
EP20010935260 |
申请日期 |
2001.05.09 |
申请人 |
SCIOS INC. |
发明人 |
CORDELL, BARBARA;HIGAKI, JEFFREY, N.;MUTZ, MITCHELL |
分类号 |
C12N9/64;C12N15/09;A61K38/00;A61K38/17;A61K38/43;A61K45/00;A61P25/28;C07K14/47;C12Q1/02;C12Q1/37;G01N33/68 |
主分类号 |
C12N9/64 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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