Syntheses of ultra-bright fluorescent silica particles

摘要

The object of the invention is to producing ultras bright fluorescent silica particles by synthesizing large nanopore silica particles with self sealed channels/pores and then stopping the synthesizing before large nanopore silica particles have been formed, wherein said sintering solution has produced nanoparticles. The large nanopore silica particles are micron size. The synthesizing is stopped by diluting said synthesizing solution with a neutralizing medium such as an aqueous solution of definite acidity of pH7 and higher an exemplary value of pH11 (sodium hydroxide). The time range for stopping the synthesizing ranges from tens of seconds to ten of minutes.

主权项

1. A method for synthesizing a plurality of ultra-bright luminescent silica particles, the method comprising the steps of:
initiating a cationic acidic templating synthesizing reaction utilized to form large nanoporous silica particles that have self-sealed nanosize pores, the synthesizing reaction including a synthesizing solution comprising a cationic surfactant at or above critical micellar concentration, water, an organosilicate or sodium silicate as a silica precursor, hydrochloride acid, and at least one luminescent dye material, and optionally at least one of formamide and glycin; and stopping, after said plurality of ultra-bright luminescent silica nanoparticles have been produced but before large nanoporous silica particles are formed, the synthesizing reaction by adding a neutralizing medium to the synthesizing reaction, wherein the pH of said neutralizing medium is 7 or higher.