| 发明名称 | C—glycolipids with enhanced Th-1 profile | ||
| 摘要 | The invention is directed to novel synthetic C-glycolipids that selectively induce a ThI-type immune response characterized by enhanced IL-12 secretion and increased activation of dendritic cells. The compounds of the invention are thereby useful in treating infections, cancers, cell proliferative disorders, and autoimmune diseases, both directly and as adjuvants. | ||
| 申请公布号 | US8883745(B2) | 申请公布日期 | 2014.11.11 |
| 申请号 | US200712302011 | 申请日期 | 2007.05.22 |
| 申请人 | New York University;The Aaron Diamond Aids Research Center For The City Of New York;Research Foundation Of The City University Of New York | 发明人 | Tsuji Moriya;Chen Guangwu;Franck Richard W.;Yang Guangli |
| 分类号 | A01N43/04;A61K31/70;A61K39/21;A61K39/12;A61K39/00;A61K39/38;A61K39/29;C07H13/06;A61K31/7004;A61K31/7042;A61K31/7028;C07H7/00;C07H15/06 | 主分类号 | A01N43/04 |
| 代理机构 | Fish & Richardson P.C. | 代理人 | Fish & Richardson P.C. |
| 主权项 | 1. A compound of formula (I)wherein X is O; Y is —CH═CH—; Q is C6-C8 alkyl substituted with phenyl; R3 is —OH and R4 is H, or R3 is H and R4 is —OH; and R5 is hydrogen;or a pharmaceutically acceptable salt or ester thereof. | ||
| 地址 | New York NY US | ||