| 发明名称 | Modulation of diacylglycerol acyltransferase 2 expression | ||
| 摘要 | Compounds, compositions and methods are provided for modulating the expression of diacylglycerol acyltransferase 2. The compositions comprise oligonucleotides, targeted to nucleic acid encoding diacylglycerol acyltransferase 2. Methods of using these compounds for modulation of diacylglycerol acyltransferase 2 expression and for diagnosis and treatment of diseases and conditions associated with expression of diacylglycerol acyltransferase 2 are provided. | ||
| 申请公布号 | US8883997(B2) | 申请公布日期 | 2014.11.11 |
| 申请号 | US201213566674 | 申请日期 | 2012.08.03 |
| 申请人 | Isis Pharmaceuticals, Inc. | 发明人 | Bhanot Sanjay;Dobie Kenneth W.;Yu Xing-Xian;Monia Brett P. |
| 分类号 | C07H21/04;C12N15/113;C07H21/02 | 主分类号 | C07H21/04 |
| 代理机构 | Knobbe Martens LLC | 代理人 | Knobbe Martens LLC |
| 主权项 | 1. An antisense compound comprising a chimeric oligonucleotide consisting of 13 to 40 nucleobases in length and comprising a nucleobase sequence comprising a portion of at least 8 contiguous nucleobases complementary to an equal length portion of an intron of a nucleic acid molecule encoding diacylglycerol acyltransferase 2 in SEQ ID NO: 18, wherein the nucleobase sequence of the chimeric oligonucleotide is at least 95% complementary to SEQ ID NO: 18 over the entire length of the chimeric oligonucleotide. | ||
| 地址 | Carlsbad CA US | ||