发明名称 N- (5S, 6S, 9R) - 5 -AMINO- 6 - (2, 3 - DIFLUOROPHENYL) -6, 7, 8, 9 - TETRAHYDRO - 5H - CYCLOHEPTA [B] PYRIDIN-9 -YL- 4 - (2 - OXO-2, 3 - DIHYDRO - 1H- IMIDAZO [4, 5 -B] PYRIDIN - 1 - YL) PIPERIDINE - 1 - CARBOXYLATE, HEMISULFATE SALT.
摘要 <p>Disclosed is a hemisulfate salt of Compound (I): and crystalline forms of the hemisulfate salt. Also disclosed are methods of using the hemisulfate salt of Compound (I) as a CGRP receptor antagonist, and pharmaceutical compositions comprising the hemisulfate salt of Compound (I). The hemisulfate salt of Compound (I) is useful in treating, preventing, or ameliorating disorders including migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases such as asthma, and chronic obstructive pulmonary disease (COPD).</p>
申请公布号 MX2014009544(A) 申请公布日期 2014.11.10
申请号 MX20140009544 申请日期 2013.02.25
申请人 BRISTOL-MYERS SQUIBB COMPANY 发明人 DANIEL RICHARD ROBERTS;RICHARD RAYMOND SCHARTMAN;CHENKOU WEI
分类号 C07D471/04;A61K31/437;A61P11/00;A61P25/00 主分类号 C07D471/04
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