摘要 |
FIELD: chemistry.SUBSTANCE: invention relates to compounds of formulaI, possessing a modulating action with respect to the CC chemokine receptor 3 (CCR3), a based on them pharmaceutical composition, versions of treatment methods and a method of controlling the CCR3 activity. In the general formula I Rand Rrepresent halogen or Calkyl; Rrepresents cyano or nitro; Rrepresentsor; Rrepresents oxo; Calkyl, optionally substituted with halogen atoms; or C(O)OR; X represents O or S; Y represents -O-, -S-, -N(R)-, -C(R)(R)- or -C(R)(NRR)-; m represents an integer number from 0 to 2; n represents 1; p represents an integer number from 0 to 2; r represents 1 or 2; and each R, R, Rand Rrepresents (a) hydrogen; (b) Ccycloalkyl; or (c) Calkyl, optionally substituted with hydroxyl, or each pair Rand Rtogether with a N atom, which they are bound to, form imidazoimidazolyl, substituted with oxo, butyl or chlorine, or heterocycle, containing 5 or 6 atoms in a cycle.EFFECT: improvement of the composition properties.41 cl, 2 tbl, 7 ex |