| 发明名称 |
ANTI-CEACAM1 RECOMBINANT ANTIBODIES FOR CANCER THERAPY |
| 摘要 |
Provided herein are recombinant monoclonal antibodies and antigen-binding portions thereof useful in inhibiting CEACAM1 in tumor cells, and methods of their use in anti-tumor proliferation and invasiveness therapies, such as the treatment of cancer, particularly pancreatic cancer. |
| 申请公布号 |
US2014328841(A1) |
申请公布日期 |
2014.11.06 |
| 申请号 |
US201214362022 |
申请日期 |
2012.11.30 |
| 申请人 |
THE BRIGHAM AND WOMEN'S HOSPITAL, INC. |
发明人 |
Blumberg Richard S.;Huang Yu-Hwa;Utku Nalan |
| 分类号 |
C07K16/28 |
主分类号 |
C07K16/28 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. An isolated CEACAM1-specific recombinant monoclonal antibody or an antigen-binding portion thereof, comprising: at least one light chain component and at least one heavy chain component, wherein said heavy chain component comprises the amino acids of SEQ ID NO:26, SEQ ID NO:28, or SEQ ID NO:30; and said light chain component comprises the amino acids of SEQ ID NO:27, SEQ ID NO:29, SEQ ID NO:31 or SEQ ID NO:32, and wherein said antibody or an antigen-binding portion thereof binds the antigen recognized by the monocloncal antibody 5F4, 34B1, or 26H7. |
| 地址 |
Boston MA US |
