| 发明名称 |
MetAP-2 INHIBITOR POLYMERSOMES FOR THERAPEUTIC ADMINISTRATION |
| 摘要 |
PROBLEM TO BE SOLVED: To provide compositions and formulations comprising methionine aminopeptidase-2 (MetAP-2) inhibitors for oral administration for treating conditions associated with or related to the overexpression or overactivity of MetAP-2.SOLUTION: A composition contains Lodamin, which is a formulation in which a MetAP-2 inhibitor such as 6-O-(N-chloroacetylcarbamoyl) fumagillol (TNP-470) is covalently linked to a PEG-PLA diblock copolymer comprising a hydrophilic poly(ethylene glycol) (PEG) moiety and a hydrophobic poly(d,L-lactic acid) (PLA) moiety. |
| 申请公布号 |
JP2014208679(A) |
申请公布日期 |
2014.11.06 |
| 申请号 |
JP20140130166 |
申请日期 |
2014.06.25 |
| 申请人 |
CHILDRENS MEDICAL CENTER CORP |
发明人 |
OFRA BENNY-RATSABY;JUDAH FOLKMAN |
| 分类号 |
A61K31/336;A61K47/34;A61K47/48;A61P3/04;A61P3/10;A61P5/14;A61P7/10;A61P9/10;A61P9/14;A61P11/00;A61P11/06;A61P15/00;A61P17/06;A61P19/02;A61P25/00;A61P25/28;A61P27/02;A61P29/00;A61P31/04;A61P31/12;A61P31/18;A61P31/22;A61P33/06;A61P35/00;A61P35/04;A61P37/06;A61P37/08;A61P43/00 |
主分类号 |
A61K31/336 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
|
| 地址 |
|
