METHODS OF INDUCING CHONDROGENESIS IN MESENCHYMAL STEM CELLS USING SYNTHETIC TRITERPENOIDS

摘要

The present invention relates to methods for enhancing differentiation of mesenchymal stem cells into chondrocytes and/or inducing chondrogenesis. The invention also relates to applications in the treatment of diseases which can affect cartilage (chondrodystrophies). The present invention also relates to methods of treatment comprising establishing a population of chondrocytes from a population of mesenchymal stem cells, which have been induced to differentiate with a synthetic triterpenoid, and administering the population of cells to a patient.

主权项

1. A method of inducing differentiation of a mesenchymal stem cell into a chondrocyte, comprising contacting a mesenchymal stem cell with a sufficient amount of a synthetic triterpenoid to induce chondrogenesis, wherein the synthetic triterpenoid is a compound of the formula:wherein Y is:
—CN or —C(O)R, wherein R is hydroxy, amino, alkoxy(C≦8), alkylamino(C≦8), substituted alkylamino(C≦8), or heteroaryl(C≦8);or a pharmaceutically-acceptable salt or tautomer of the formula.