Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof

摘要

The present invention provides compounds that function as modulators of mitochondrial aldehyde dehydrogenase-2 (ALDH2) activity; and pharmaceutical compositions comprising the compounds. The present invention provides therapeutic methods involving administering a subject compound, or a subject pharmaceutical composition. The present invention further provides assays for identifying agonists of ALDH2. 4') (10 0 m CY)E 0 /o C.) U) 0 Cr- 0 D0C D 0 C fL!AIlB oplewUAzue U! GeenuI %0 o N r1 CO -~ 404 0 C oc co < n 0 Co 0 Emm C 0o N N 0 7 AwAleoiwzu !OUJU