| 发明名称 |
NUCLEIC ACID PARTICLES, METHODS AND USE THEREOF |
| 摘要 |
The present invention provides, among other things, a particle which includes a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. Methods of making and using of provided particles are also disclosed. |
| 申请公布号 |
US2014328931(A1) |
申请公布日期 |
2014.11.06 |
| 申请号 |
US201414190983 |
申请日期 |
2014.02.26 |
| 申请人 |
Massachusetts Institute of Technology |
发明人 |
Hammond Paula T.;Lee Jong Bum;Roh Young Hoon |
| 分类号 |
A61K9/16;C12N15/113;C12P19/34;A61K31/713;A61K45/06 |
主分类号 |
A61K9/16 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A particle, comprising:
a core comprised of self-assembled one or more nucleic acid molecules, the core being characterized by an ability to adopt at least two configurations: a first configuration having a first greatest dimension greater than 2 μm and; a second configuration having a second greatest dimension less than 500 nm, wherein addition of a film coating converts the core from its first configuration to its second configuration. |
| 地址 |
Cambridge MA US |
