发明名称 |
METHODS OF TREATING CANCER |
摘要 |
Methods of treating cancers comprising FGFR1 gene amplification, FGFR1 overexpression, FGFR3 overexpression, FGFR3 amplification, FGF2 overexpression, and/or FGF2 gene amplification are provided. In some embodiments, the methods comprise administering a fibroblast growth factor receptor 1 (FGFR1) extracellular domain (ECD) and/or an FGFR1 ECD fusion molecule. In some embodiments, the methods comprise administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one additional therapeutic agent. In some embodiments, methods of treating cancers comprising administering a FGFR1 ECD and/or an FGFR1 ECD fusion molecule in combination with at least one chemotherapeutic agent are provided. |
申请公布号 |
WO2014179448(A2) |
申请公布日期 |
2014.11.06 |
申请号 |
WO2014US36140 |
申请日期 |
2014.04.30 |
申请人 |
FIVE PRIME THERAPEUTICS, INC.;GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED |
发明人 |
HAMBLETON, JULIE;BLEAM, MAUREEN R.;DEYOUNG, MAURICE P.;FERRON-BRADY, GERALDINE;KUMAR, RAKESH;OTTESEN, LONE |
分类号 |
A61K38/17 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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地址 |
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