| 发明名称 |
THERAPEUTIC PEPTIDES |
| 摘要 |
The present invention relates to novel analogs of PYY that have an improved therapeutic profile when compared to native human PYY. These novel PYY analogs are useful in the treatment of obesity, diabetes, and other disorders. |
| 申请公布号 |
US2014329742(A1) |
申请公布日期 |
2014.11.06 |
| 申请号 |
US201414265831 |
申请日期 |
2014.04.30 |
| 申请人 |
GlaxoSmithKline Intellectual Property (No. 2) Limited |
发明人 |
Dock Steven Thomas;Carpenter Andrew James;Hunter, III Robert Neil;Wu Yulin;Srivastava Ved P. |
| 分类号 |
C07K14/575;A61K38/26 |
主分类号 |
C07K14/575 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A polypeptide comprising the amino acid sequence:(SEQ ID NO: 1)ProLysProGluXaa1ProGlyXaa2AspAlaSerXaa3GluGluXaa4Xaa5Xaa6TyrTyrAlaXaa7LeuArgXaa8TyrXaa9AsnTrpXaa10ThrArgGlnArgTyr or a salt thereof, wherein: Xaa1 is Ala, His, or Ser; Xaa2 is Glu or Lys; Xaa3 is Pro or Ala; Xaa4 is Leu or Trp; Xaa5 is Asn, Ala, or Thr; Xaa6 is Arg or Lys; Xaa7 is Ser, Asp, or Ala; Xaa8 is His or Lys; Xaa9 is Leu or Ile; and Xaa10 is Val or Leu. |
| 地址 |
Brentford GB |
