发明名称 |
METHOD CAPABLE OF MASSIVELY AND RAPIDLY INDUCING MESENCHYMAL STEM CELLS TO TRANSDETERMINE INTO HEMATOPOIETIC STEM CELLS OF HIGH PURITY |
摘要 |
The present invention presents a method which can rapidly induce large-scale and high-purity mesenchymal stem cells to transdetermine into hematopoietic stem cells, includes the steps as follows: 1)preparation of homogeneous medium of mesenchymal stem cells; 2)Combination of a plurality of small RNA molecules; 3)assembling and transfection of nanoparticles of nucleic acids and polypeptides; 4)inducing and amplifying medium of post-transdetermined hematopoietic stem cells; 5)activating multiple hemopoiesis-related genes. It resolves the technical bottleneck problem of cell matching difficulties, immune rejection and quantity limitation of hematopoietic stem cells in prior art in hematopoietic stem cell treatment. |
申请公布号 |
EP2799552(A1) |
申请公布日期 |
2014.11.05 |
申请号 |
EP20130834380 |
申请日期 |
2013.03.04 |
申请人 |
BEIJING GINKGO BIOSCIENCE CO., LTD. |
发明人 |
YIN, QINWEI |
分类号 |
C12N5/0789;C12N15/11;C12N15/87 |
主分类号 |
C12N5/0789 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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