Tumor cell-killing peptides

摘要

The present invention provides a tumor cell-killing peptide and a pharmaceutical composition for treating a cancer. The tumor cell-killing peptide of the present invention selectively homes into tumor cells so that it can induce the death of tumor cells effectively while minimizing the harming of normal cell.

主权项

1. A tumor cell-killing peptide, comprising:
(a) a mitochondria targeting domain (MTD) at its C-terminal region consisting of an amino acid sequence selected from the group consisting of the amino acid sequences of SEQ ID NOs:1 and 4-7; and (b) a tumor homing motif at its N-terminal region, consisting of the amino acid sequence of SEQ ID NO:2 or SEQ ID NO:3; and (c) a peptide linker that links the MTD to the tumor homing motif.