| 发明名称 | Use of an IL12 receptor-beta 1 splice variant to diagnose active tuberculosis | ||
| 摘要 | The present invention describes compositions for both diagnostic and therapeutic applications. In one embodiment, the present invention contemplates a method of identifying an active M. tuberculosis infection. In another embodiment, the present invention contemplates a method of monitoring a M. tuberculosis infection. In yet another embodiment, the present invention contemplates a method of monitoring a patient's response to treatment for an active M. tuberculosis infection. In a further embodiment, the present invention contemplates a method of monitoring a patient's response to treatment for an active M. tuberculosis infection. | ||
| 申请公布号 | US8877212(B2) | 申请公布日期 | 2014.11.04 |
| 申请号 | US201313764289 | 申请日期 | 2013.02.11 |
| 申请人 | Trudeau Institute | 发明人 | Robinson Richard T.;Cooper Andrea M. |
| 分类号 | A61K39/04;C12Q1/68;C07H21/04 | 主分类号 | A61K39/04 |
| 代理机构 | Medlen & Carroll, LLP | 代理人 | Medlen & Carroll, LLP |
| 主权项 | 1. A method of identifying an active M. tuberculosis infection, comprising: a) providing a patient infected with M. tuberculosis, b) determining the amount of IL12Rβ1 isoform 1 mRNA and IL12Rβ1 isoform 2 mRNA in a cell from said patient, wherein said cell is a peripheral blood mononuclear cell, c) diagnosing the patient as having an active M. tuberculosis infection if the amount of IL12Rβ1 isoform 2 mRNA is greater than the amount of IL12Rβ1 isoform 1 mRNA, d) initiating a therapeutic treatment on said patient with an active M. tuberculosis infection. | ||
| 地址 | Saranac Lake NY US | ||