Methods and compositions for the treatment of cancer and infectious disease using alpha (2) macroglobulin-antigenic molecule complexes

摘要

The present invention relates to the use of alpha (2) macroglobulin complexes isolated from the serum of a mammal. The invention also relates to methods for making such complexes and compositions comprising alpha (2) macroglobulin complexes, isolated from the serum of a mammal, wherein such compositions are used in methods for the treatment and prevention of cancer and infectious disease. The invention also relates to methods for treating and preventing cancer and infectious disease using such complexes comprising, isolated from the serum of a mammal. The invention also encompasses methods for production of alpha (2) macroglobulin complexes.

主权项

1. A method for preparing purified alpha (2) macroglobulin-antigenic molecule complexes comprising (a) purifying endogenous alpha (2) macroglobulin-antigenic molecule complexes from serum from a patient having a cancerous tumor or an infectious disease, wherein said complexes comprise an antigenic molecule having the antigenicity of said cancerous tumor or an infectious agent of said infectious disease, respectively, wherein said complexes when purified from said patient having said cancerous tumor, are in an amount effective to treat said cancerous tumor, and wherein said complexes when purified from said patient having said infectious disease, are in an amount effective to treat said infectious disease; and (b) formulating the purified alpha (2) macroglobulin-antigenic molecule complexes in a compatible pharmaceutical carrier.