| 主权项 |
1. A compound of formula (I) wherein n is 0, 1, 2, 3 or 4; x is a single bond or double bond; Y is —C(O)— or —S(O)2—; R1 hydrogen, cyano, alkyl, haloalkyl, alkenyl, alkynyl, hydroxy, alkoxy, cycloalkyl, heterocycloalkyl, aryl, aryl annelated to heterocycloalkyl, heteroaryl, —NR7R8, —C(O)—NR7R8, or —S(O)2—R7, wherein alkyl, haloalkyl, and alkoxy are each optionally substituted by one to three independent R5 and wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R6; R2, R3, and R4 are each independently hydrogen, halogen, alkyl, haloalkyl, hydroxy, alkoxy or haloalkoxy; R5 is cyano, hydroxy, alkoxy, cycloalkyl, heterocycloalkyl, aryl, or heteroaryl, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R6; R6 is halogen, cyano, alkyl, haloalkyl, hydroxy, alkoxy, haloalkoxy, oxo, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, or —S(O)2—R7, wherein cycloalkyl, heterocycloalkyl, aryl, and heteroaryl are each optionally substituted by one to three independent R9; and R7, R8, and R9 are each independently hydrogen, alkyl, cycloalkyl, cycloalkylalkyl, heterocycloalkyl, heterocycloalkylalkyl, aryl, or heteroaryl; or a pharmaceutically acceptable salt or ester thereof. |
