| 摘要 |
Disclosed are compounds represented by formula (I), pharmaceutically acceptable salts thereof, solvates thereof, and solvates of the pharmaceutically acceptable salts thereof,;
wherein R1, R2, R3, R4, W and
;
are as defined in the present application. |
| 主权项 |
1. A compound of formula (I), a pharmaceutically acceptable salt thereof, a solvate thereof, or a solvate of the pharmaceutically acceptable salt thereof, wherein: R1 represents H, F, OH, optionally substituted hydrocarbyl or optionally substituted hydrocarboxy; R2 represents H or OH; W represents O or NH; R3 represents H, F, OH, optionally substituted hydrocarbyl or optionally substituted hydrocarboxy; R4 represents F or OR7, wherein R7 represents H or 2-pyranyl; whereinis selected from the group consisting of a group represented by formula (II), a group represented by formula (V) and a group represented by formula (VI), wherein, n represents 1 or 2; X represents C═O or CR21R22; Y represents C═O or CR21R22; Q represents CH or N; R10, R11, R12, R13, R15, R16, R21 and R22 separately represent H, F, Cl, CN, OH, COOC1-4 hydrocarbyl, OC1-4 hydrocarbyl, C1-4 hydrocarbyl or NR18R19; R18 and R19 separately represent H or C1-6 hydrocarbyl, or NR18R19 together represents pyrrolidin-1-yl, piperidin-1-yl or morpholin-1-yl. |
