Process for preparing pan-cdk inhibitors of the formula (i), and intermediates in the preparation

摘要

Provided is a process and intermediates for preparing pan-CDK inhibitors of formula (I), where R4 is a C1-C6 alkyl group or a C3-C7 cycloalkyl ring, particularly (2R,3R)-3-{ [2-{ [ 4-(S-cyclopropylsulphonimidoyl)phenyl ]amino} -5-( trifluoromethyl)pyrimidin-4-yl]oxy} butan-2-ol. Pan-CDK inhibitors have anti-tumour activity.