| 摘要 |
Disclosed herein is an agomelatine hydrobromide hydrate of formula I and a method for its production wherein agomelatine is dissolved in organic solvent, preferablly ethyl acetate, before being reacted with aqueous HBr solution to produce said hydrobromide hydrate salt. The salt is useful in the treatment melatoninergic system disorders, sleep disorders, stress, anxiety, seasonal affective disorder, major depression, cardiovascular diseases, digestive system diseases, insomnia and fatigue caused by jet lag, schizophrenia, phobia or depression disorders. |
