| 摘要 |
Disclosed herein is a process for the preparation of N-(2-(6-fluoro-1H-indol-3-yl)ethyl(2,2,3,3-tetrafluoropropoxy)benzylamine and pharmaceutically acceptable salts thereof. The disclosure particularly relates to a process for the preparation of the compound of formula (IV) comprising the steps of: (a) mixing (6-fluoro-1H-indol-3-yl)acetonitrile, 25 % NH3 in water and a transition metal catalyst (such as RaNi which is an activated Nickel Catalyst) in an alcoholic solvent such as methanol; and (b) hydrogenating the mixture with H2. Also disclosed is a process for the preparation of a compound of formula (II), which comprises the steps of: (a) mixing a solution of diethoxymethane, water and formic acid; (b) adding the solution of step (a) to a mixture of 6-fluoroindole, methylamine and acetic acid; and (c) adding an aqueous basic solution (such as sodium hydroxide NaOH). |
