| 发明名称 |
COMPOUNDS AND METHODS TO TREAT ORGANOPHOSPHORUS POISONING |
| 摘要 |
Organophosphate (OP) nerve agents and pesticides are potent inhibitors of acetylcholinesterase (AChE). Though oxime nucleophiles can reactivate an AChE-phosphyl adduct, the adduct can undergo a reaction called aging, leading to an aged-AChE adduct. The invention provides compounds and methods that can be used to reactivate an aged-AChE adduct. Such compounds and methods are useful to counteract organophosphorus poisoning. |
| 申请公布号 |
US2014323473(A1) |
申请公布日期 |
2014.10.30 |
| 申请号 |
US201414163859 |
申请日期 |
2014.01.24 |
| 申请人 |
University of Iowa Research Foundation |
发明人 |
Quinn Daniel;Topczewski Joseph John |
| 分类号 |
C07D213/64;A61K31/46;A61K31/5513;A61K31/44 |
主分类号 |
C07D213/64 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for reactivating an aged-AChE adduct comprising contacting the aged-AChE adduct with an alkylating agent that reactivates the aged-AChE adduct to provide an AChE-OP adduct. |
| 地址 |
Iowa City IA US |
