| 主权项 |
1. A compound of formula (I) or a salt form thereof, wherein
A is NR11, O, or S; M-Q-X is a group of formula G is a group of formulaR1, R2, R11, and R12 are independently chosen from H, C1-6alkyl optionally substituted by 1-13 R19, C2-6alkenyl optionally substituted by 1-11 R19, C2-6alkynyl optionally substituted by 1-9 R19, C6-11aryl optionally substituted by 1-11 R19, C2-16arylalkyl optionally substituted by 1-19 R19, C3-11cycloalkyl optionally substituted by 1-21 R19, C4-12cycloalkylalkyl optionally substituted by 1-32 R19, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R19, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R19, 5-15 membered heteroaryl optionally substituted by 1-15 R19, 6-21 membered heteroarylalkyl optionally substituted by 1-27 R19, and —OR20;R3, R4, R5, R6, R7, R8, R9, R10, R12, R13, R14, R15, R16, and R18 are independently chosen from H, C1-6alkyl optionally substituted by 1-13 R19, C2-6alkenyl optionally substituted by 1-11 R19, C2-6alkynyl optionally substituted by 1-9 R19, C6-11aryl optionally substituted by 1-11 R19, C2-16arylalkyl optionally substituted by 1-19 R19, C3-11cycloalkyl optionally substituted by 1-21 R19, C4-17cycloalkylalkyl optionally substituted by 1-32 R19, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R19, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R19, 5-15 membered heteroaryl optionally substituted by 1-15 R19, 6-21 membered heteroarylalkyl optionally substituted by 1-27 R19, halogen, —CN, —C(═O)R20, —C(═O)OR20, —C(═O)NR22R23, —C(═O)C(═O)R20, —C(═NR25)R20, —C(═NR25)NR22R23, —C(═NOH)NR22-R23, —C(═NOR26)R20, —C(═NNR22R23)R20, —C(═NNR24C(═O)R21)R20, —C(═NNR24C(═O)OR21)R20, —C(═S)NR22R23, —NC, —NO2, —NR22R23, —NR24NR22R23, —N═NR24, —NR24OR26, —NR24C(═O)R20, —NR24C(═O)C(═O)R20, —NR24C(═O)OR21, —NR24C(═O)C(═O)OR21, —NR24C(═O)NR22R23, —NR24C(═O)NR24C(═O)R20, —NR24C(═O)NR24C(═O)OR20, —NR24C(═NR25)NR22R23, —NR24C(═O)C(═O)NR22R23, —NR24C(═S)R20, —NR24C(═S)OR20, —NR24C(═S)NR22R23, —NR24S(═O)2R21, —NR24S(═O)2NR22R23, —NR24P(O)R28R28, —NR24P(O)(NR22R23)(NR22R23), —NR24P(═O)(OR20)(OR20), —NR24P(═O)(SR20)(SR20), —OR20, —OCN, —OC(═O)R20, —OC(═O)NR22R23, —OC(═O)OR20, —OC(═NR25)NR22R23, —OS(═O)R20, —OS(═O)2R20, —OS(═O)2OR20, —OS(═O)2NR22R23, —OP(═O)R28R28, —OP(═O)(NR22R23)(NR22R23), —OP(═O)(OR20)(OR2), —OP(═O)(SR20)(SR20), —Si(R24)3, —SCN, —S(═O)nR20, —S(═O)2OR20, —SO3R27, —S(═O)2NR22R23, —S(═O)NR22R23, —SP(═O)R28R28, —SP(═O)(NR22R23)(NR22R23), —SP(═O)(OR20)(OR20), —SP(═O)(SR20)(SR20), —P(═O)R28R28, —P(═O)(NR22R23)(NR22R23), —P(═O)(OR20)(OR20), and —P(═O)(SR20)(SR20);any of R1 and R2, R1 and R3, R1 and R5, R1 and R11, R4 and R11, R6 and R11, and R16 and R17 can, together with the atoms linking them, form a 3-15 membered heterocycloalkyl optionally substituted by 1-28 R19 or a 5-15 membered heteroaryl optionally substituted by 1-15 R19;any of R3 and R6, R7 and R8, R9 and R10, R12 and R13, and R14 and R15 can, together with the atoms linking them, form a C6-11aryl optionally substituted by 1-11 R19, C3-11cycloalkyl optionally substituted by 1-21 R19, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R19 or a 5-15 membered heteroaryl optionally substituted by 1-15 R19;R3 and R5 or R4 and R6 can together form a double bond;any of R3 and R4, and R5 and R6 can together form ═O, ═NR20, ═NOR20, or ═S;R19 at each occurrence is independently chosen from C1-6alkyl optionally substituted by 1-13 R39, C2-6alkenyl optionally substituted by 1-11 R39, C2-6alkynyl optionally substituted by 1-9 R39, C6-11aryl optionally substituted by 1-11 R39, C2-16arylalkyl optionally substituted by 1-19 R39, C3-11cycloalkyl optionally substituted by 1-21 R39, C4-12cycloalkylalkyl optionally substituted by 1-32 R39, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R39, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R39, 5-15 membered heteroaryl optionally substituted by 1-15 R39, 6-21 membered heteroarylalkyl optionally substituted by 1-27 R39, halogen, —CN, —C(═O)R30, —C(═O)OR30, —C(═O)NR32R33, —C(═O)C(═O)R30, —C(═NR35)R30, —C(═NR35)NR32R33, —C(═NOH)NR32R33, —C(═NOR36)R30, —C(═NNR32R33)R30, —C(═NNR34C(═O)R31)R30, —C(═NNR34C(═O)OR31)R30, —C(═S)NR32R33, —NC, —NO2, —NR32R33, —NR34NR32R33, —N═NR34, ═NR30, ═NOR30, —NR34OR36, —NR34C(═O)R30, —NR34C(═O)C(═O)R30, —NR34C(═O)OR31, —NR34C(═O)C(═O)OR31, —NR34C(═O)NR32R33, —NR34C(═O)NR34C(═O)R30, —NR34C(═O)NR34C(═O)OR30, —NR34C(═NR35)NR32R33, —NR34C(═O)C(═O)NR32R33, —NR34C(═S)R30, —NR34C(═S)OR30, —NR34C(═S)NR32R33, —NR34S(═O)2R31, —NR34S(═O)2NR32R33, —NR34P(═O)R38R38, —NR34P(═O)(NR32R33)(NR32R33), —NR34P(═O)(OR30)(OR30), —NR34P(═O)(SR30)(SR30), —OR30, ═O, —OCN, —OC(═O)R30, —OC(═O)NR32R33, —OC(═O)OR30, —OC(═NR35)NR32R33, —OS(═O)R30, —OS(═O)2R30, —OS(═O)2OR30, —OS(═O)2NR32R33, —OP(═O)R38R38, —OP(═O)(NR32R33)(NR32R33), —OP(═O)(OR30)(OR30), —OP(═O)(SR30)(SR30), —Si(R34)3, —SCN, ═S, —S(═O)nR30, —S(═O)2OR30, —SO3R37, —S(═O)2NR32R33, —S(═O)NR32R33, —SP(═O)R38R38, —SP(═O)(NR32R33)(NR32R33), —SP(═O)(OR30)(OR30), —SP(═O)(SR30)(SR30), —P(═O)R38R38, —P(═O)(NR32R33)(NR32R33), —P(═O)(OR30)(OR30), and —P(═O)(SR30)(SR30);R20, R21, R24, R25, R26, R27, R30, R31, R34, R35, R36 and R37 at each occurrence is independently chosen from H, C1-6allyl optionally substituted by 1-13 R49, C2-6alkenyl optionally substituted by 1-11 R49, C2-6alkynyl optionally substituted by 1-9 R49, C6-11aryl optionally substituted by 1-11 R49, C2-16arylalkyl optionally substituted by 1-19 R49, C3-11cycloalkyl optionally substituted by 1-21 R49, C4-12cycloalkylalkyl optionally substituted by 1-32 R49, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R49, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R49, 5-15 membered heteroaryl optionally substituted by 1-15 R49, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R49;R28 and R38 at each occurrence is independently chosen from C1-6allyl optionally substituted by 1-13 R49, C2-6alkenyl optionally substituted by 1-11 R49, C2-6alkynyl optionally substituted by 1-9 R49, C6-11aryl optionally substituted by 1-11 R49, C2-16arylalkyl optionally substituted by 1-19 R49, C3-11cycloalkyl optionally substituted by 1-21 R49, C4-12cycloalkylalkyl optionally substituted by 1-32 R49, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R49, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R49, 5-15 membered heteroaryl optionally substituted by 1-15 R49, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R49;R22, R23, R32 and R33 at each occurrence is independently chosen from H, C1-6allyl optionally substituted by 1-13 R59, C2-6alkenyl optionally substituted by 1-11 R59, C2-6alkynyl optionally substituted by 1-9 R59, C6-11aryl optionally substituted by 1-11 R59, C2-16arylalkyl optionally substituted by 1-19 R59, C3-11cycloalkyl optionally substituted by 1-21 R59, C4-12cycloalkylalkyl optionally substituted by 1-32 R59, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R59, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R59, 5-15 membered heteroaryl optionally substituted by 1-15 R59, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R59; or any R22 and R23 and/or R32 and R33 may form, together with the nitrogen atom to which they are attached, a 3-15 membered heterocycloalkyl optionally substituted by 1-28 R69 or a 5-15 membered heteroaryl optionally substituted by 1-15 R69;R39, R49, R59 and R69 at each occurrence is independently chosen from C1-6alkyl optionally substituted by 1-13 R79, C2-6alkenyl optionally substituted by 1-11 R79, C2-6alkynyl optionally substituted by 1-9 R79, C6-11aryl optionally substituted by 1-11 R79, C7-16arylalkyl optionally substituted by 1-19 R79, C3-11cycloalkyl optionally substituted by 1-21 R79, C4-17cycloalkylalkyl optionally substituted by 1-32 R79, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R79, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R79, 5-15 membered heteroaryl optionally substituted by 1-15 R29, 6-21 membered heteroarylalkyl optionally substituted by 1-27 R79, halogen, —CN, —C(═O)R70, —C(═O)OR70, —C(═O)NR72R73, —C(═O)C(═O)R76, —C(═NR75)R70, —C(═NR75)NR72R73, —C(═NOH)NR72R73, —C(═NOR76)R70, —C(═NNR72R73)R70, —C(═NNR74C(═O)R71)R70, —C(═NNR74C(═O)OR71)R70, —C(═S)NR72R73, —NC, —NO2, —NR72R73, —NR74NR72R73, —N═NR74, ═NR70, ═NOR70, —NR74OR76, —NR74C(═O)R70, —NR74C(═O)C(═O)R70, —NR74C(═O)OR71, —NR74C(═O)C(═O)OR71, —NR74C(═O)NR72R73, —NR74C(═O)NR74C(═O)R76, —NR74C(═O)NR74C(═O)OR70, —NR74C(═NR75)NR72R73, —NR74C(═O)C(═O)NR72R73, —NR74C(═S)R70, —NR74C(═S)OR70, —NR74C(═S)NR72R73, —NR74S(═O)2R71, —NR74S(═O)2NR72R73, —NR74P(═O)R78R78, —NR74P(═O)(NR72R73)(NR72R73), —NR74P(═O)(OR70)(OR70), —NR74P(═O)(SR70)(SR70), —OR70, ═O, —OCN, —OC(═O)R70, —OC(═O)NR72R73, —OC(═O)OR70, —OC(═NR75)NR72R73, —OS(═O)R70, —OS(═O)2R70, —OS(═O)2OR70, —OS(═O)2NR72R73, —OP(═O)R78R78, —OP(═O)(NR72R73)(NR72R73), —OP(═O)(OR70)(OR70), —OP(═O)(SR70)(SR70), —Si(R74)3, —SCN, ═S, —S(═O)nR70, —S(═O)2OR70, —SO3R77, —S(═O)2NR72R73, —S(═O)NR72R73, —SP(═O)R78R78, —SP(═O)(NR72R73)(NR72R73), —SP(═O)(OR70)(OR70), —SP(═O)(SR70)(SR70), —P(═O)R78R78, —P(═O)(NR72R73)(NR72R73), —P(═O)(OR70)(OR70), and —P(═O)(SR70)(SR70);R70, R71, R74, R75, R76 and R77 at each occurrence is independently chosen from H, C1-6alkyl optionally substituted by 1-13 R89, C2-6alkenyl optionally substituted by 1-11 R89, C2-6alkynyl optionally substituted by 1-9 R89, C6-11aryl optionally substituted by 1-11 R89, C7-16arylalkyl optionally substituted by 1-19 R89, C3-11cycloalkyl optionally substituted by 1-21 R89, C4-17cycloalkylalkyl optionally substituted by 1-32 R89, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R89, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R89, 5-15 membered heteroaryl optionally substituted by 1-15 R89, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R89;R72 and R73 at each occurrence is independently chosen from H, C1-6alkyl optionally substituted by 1-13 R99, C2-6alkenyl optionally substituted by 1-11 R99, C2-6alkynyl optionally substituted by 1-9 R99, C6-11aryl optionally substituted by 1-11 R99, C7-16arylalkyl optionally substituted by 1-19 R99, C3-11cycloalkyl optionally substituted by 1-21 R99, C4-17cycloalkylalkyl optionally substituted by 1-32 R99, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R99, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R99, 5-15 membered heteroaryl optionally substituted by 1-15 R99, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R99; or any R72 and R73 may form, together with the nitrogen atom to which they are attached, a 3-15 membered heterocycloalkyl optionally substituted by 1-28 R109 or a 5-15 membered heteroaryl optionally substituted by 1-15 R109;R78 at each occurrence is independently chosen from C1-6alkyl optionally substituted by 1-13 R89, C2-6alkenyl optionally substituted by 1-11 R89, C2-6alkynyl optionally substituted by 1-9 R89, C6-11aryl optionally substituted by 1-11 R89, C7-16arylalkyl optionally substituted by 1-19 R89, C3-11cycloalkyl optionally substituted by 1-21 R89, C4-17cycloalkylalkyl optionally substituted by 1-32 R89, 3-15 membered heterocycloalkyl optionally substituted by 1-28 R89, 4-21 membered heterocycloalkylalkyl optionally substituted by 1-40 R89, 5-15 membered heteroaryl optionally substituted by 1-15 R89, and 6-21 membered heteroarylalkyl optionally substituted by 1-27 R89;R79, R89, R99 and R109 at each occurrence is independently chosen from C1-6alkyl optionally substituted by 1-13 halogen, C2-6alkenyl, C2-6alkynyl, C6-11aryl, C7-16arylalkyl, C3-11cycloalkyl, C4-17cycloalkylalkyl, 3-15 membered heterocycloalkyl, 4-21 membered heterocycloalkylalkyl, 5-15 membered heteroaryl, 6-21 membered heteroarylalkyl, halogen, CN, C(═O)R110, C(═O)OR110, —C(═O)NR100R110, —C(═O)C(═O)R110, —C(═NR110)R110, —C(═NR110)NR110R110, —C(═NOH)NR110R110, —C(═NOR110)R110, —C(═NNR110R110)R110, —C(NNR110C(═O)R110)R110, —C(═NNR110C(═O)OR110)R110, —C(═S)NR110R110, —NC, —NO2, —NR110R110, —NR110NR110R110, —N═NR110═NR110, ═NOR110, —NR110OR110, —NR110C(═O)R110, —NR110C(═O)C(═O)R110, —NR110C(═O)OR110, NR110C(═O)C(═O)OR110, —NR110C(═O)NR110R110, NR110C(═O)NR110C(═O)R110, —NR110C(═O)NR110C(═O)OR110, —NR110C(═NR110)NR110R110, —NR110C(═O)C(═O)NR110R110, —NR110C(═S)R110, —NR110C(═S)OR110, —NR110C(═S)NR110R110, —NR110S(═O)2R110, —NR110S(═O)2NR110R110, —NR110P(═O)R111R111, —NR110P(═O)(NR110R110)(NR110R110), —NR110P(═O)(OR110)(OR110), —NR110P(═O)(SR110)(SR110), —OR110, ═O, —OCN, —OC(═O)R110, —OC(═O)NR110R110, —OC(═O)OR110, —OC(═NR110)NR110R110, —OS(═O)R110, —OS(═O)2R110, —OS(═O)2OR110, —OS(═O)2NR110R110, —OP(═O)R111R111, —OP(═O)(NR110R110)(NR110R110), —OP(═O)(OR110)(OR110), —OP(═O)(SR110)(SR110), —Si(R110)3, —SCN, ═S, —S(═O)nR110, S(═O)2OR110, —SO3R110, —S(═O)2NR110R110, —S(═O)NR110R110, —SP(═O)R111R111, —SP(═O)(NR110R110)(NR110R110), —SP(═O)(OR110)(OR110, —SP(═O)(SR110)(SR110), P(═O)R111R111, —P(═O)(NR110R110)(NR110R110), —P(═O)(OR110)(OR110) and P(═O)(SR110)(SR110);R110 at each occurrence is independently chosen from H, C1-6alkyl and C1-6-haloalkyl;R111 at each occurrence is independently chosen from C1-6alkyl and C1-6-haloalkyl; andn at each occurrence is independently chosen from 0, 1, and 2. |
