| 主权项 |
1. A compound of Formula (I):or a pharmaceutically acceptable salt thereof, wherein
W is selected from the group consisting of (a) C3-8cycloalkyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8 alkyl, amino, hydroxy, C1-8alkylcarbonyl, aminocarbonyl, C1-8alkoxycarbonylamino, arylC1-8alkoxycarbonylamino, aryl and heterocyclylC1-8alkylene; (b) C1-8 alkyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of amino, oxo, C1-8alkoxy, C2-8alkynyl, cyano, aminocarbonyl, C1-8haloalkylene, hydroxy, halogen, C3-8cycloalkyl, and aryl; (c) C1-8 alkylC3-8heterocyclyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8alkyl, C1-8alkylcarbonyl, C1-8alkylsulfonyl; and aminocarbonyl; (d) aryl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8haloalkylene, carboxy, acyl, acylamino, cyano, amino, aminocarbonyl, aminosulfonyl, sulfonyl, nitro, hydroxy, C1-8alkoxy, aryloxy, halo, sulfonylamino, C3-8cycloalkyl, aryl, heterocyclyl C1-8alkylsulfonyl, C1-8alkylcarbonylheterocyclyl and heteroaryl; (e) heteroaryl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8alkyl, C1-8alkylcarbonyl, aminocarbonyl, C1-8alkoxycarbonyl, amino, C1-8 alkoxycarbonylamino, arylC1-8alkoxycarbonylamino, hydroxy, C1-8 alkoxy, C1-8alkylsulfonyl, oxo, halo, aryl and heterocyclylC1-8alkylene; (f) C3-8heterocyclyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8alkyl, C1-8alkoxycarbonyl and oxo; R1 is selected from the group consisting of H, C1-8 alkyl, amino, aminocarbonyl, hydroxy, C1-8 alkoxy, C1-8 haloalkylene, C2-8 alkenyl, C2-8 alkynyl, oxo, cyano, C1-8 alkoxycarbonyl, C3-8 cycloalkyl, aryl and heterocyclyl; and each heterocyclyl is optionally substituted with from 1 to 4 substituents selected from the group consisting of C1-8 alkyl, halo, oxo, amino, C1-8alkoxy, C1-8alkylcarbonyl, arylC1-8 alkoxycarbonyl, aminocarbonyl, arylC1-8 alkylenecarbonyl and C1-8 alkylsulfonyl; Y is selected from the group consisting ofand
d) heterocyclyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of C1-8alkyl, C1-8alkenyl, amino, cyanoC1-8alkylene, aminocarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, oxoC1-8alkylene, hydroxyalkyl, carboxy, haloC1-8alkylene, cyano and oxo and halo e) phenyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkyl, alkoxy and halo; f) pyridyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of alkoxy; g) indinlyl, optionally substituted with from 1 to 4 substituents independently selected from the group consisting of hydroxyl and oxo; R1a is selected from the group consisting of oxo, hydroxy, alkoxy, NH2, N3, triazinyl, HC(O)NH—, NCCH2NH—, HOCH2CH2NH—, R1uOCONH—, R1vNHCH(CH3)NH—, N+(O−) H2, N(O), N(═CH2), R1wOC(O)NH—, and C1-8alkylC(O)NH—; R1b is selected from the group consisting of H, hydroxyl, fluoro, combined to form an oxo group, or one R1b is combined with R1a to form a pyridyl ring and the other R1b is null; R1c is selected from the group consisting of H, fluoro, hydroxyl, alkoxy, benzyloxy; R1d is independently selected from H, alkoxycarbonyl, alkylaminocarbonyl, dialkylaminocarbonyl, and heterocyclylcarbonyl; R1e is independently selected from H and aminocarbonyl; R1u is selected from the group consisting of H, alkyl, and heterocyclyl optionally substituted with one to four substitutents independently selected from the group consisting of oxo, hydroxy, and carboxy; R1v is a sugar moiety; R1w is a moiety of formula V attached via a covalent bond at R1a wherein Y is each R1f is selected from the group consisting of H, C1-8alkyl, C1-8haloalkylene, phenyl, C3-8cycloalkyl, hydroxyC1-8alkylene, NH2, C1-8alkylamino, C1-8 alkoxycarbonylaminoC1-8 alkylene, C3-8cycloalkylC1-8 alkylene, heteroaryl, alkylene, C1-8alkylsulfonylC1-8 alkylene, aminocarbonyl, C1-8alkoxyC1-8alkyl, haloC1-8alkylene, aryl and heterocyclyl; wherein the aryl is optionally substituted by hydroxy, C1-8alkoxy, halo or haloC1-8alkylene; R1g is independently selected from the group consisting of H, C1-8alkyl, C3-8cycloalkyl, and C3-8cycloalkylC1-8 alkylene; R1x is H, alkyl, haloalkyl or combined with R1y to form a cycloalkyl group; R1y is selected from the group consisting of H, C1-8alkyl, C1-8alkylamino, amino aminoC1-8alkylene, carboxy, C1-8alkylaminoC1-8alkylene, C1-8alkoxyC1-8alkylene, hydroxyC1-8alkylene; carboxyC1-8alkylene, C3-8cycloalkylC1-8alkylene, aryloxyC1-8alkylene, arylC1-8alkylene, heteroarylC1-8alkylene, and hydroxyC1-8alkoxy; or R1y may be combined with R1f or R1x and the atoms to which they are attached to form a C3-8 cycloalkyl or heterocyclyl ring optionally substituted with one to three groups independently selected from hydroxy, halo, oxo and amino; R1z is selected from the group consisting of H, amino, C1-8alkylamino, hydroxycarbonylamino, C1-8alkoxycarbonylamino, arylC1-8alkoxycarbonylamino and hydroxy; and the wavy line indicates the point of attachment to the rest of the molecule wherein the wavy line indicates the point of attachment to the rest of the molecule. |
