Method For Reducing Leachables and Extractables In Syringes

摘要

The present invention relates to a method of producing syringes. Said method comprises fixing a needle to a syringe body by use of an adhesive followed by subjecting the syringes thus obtained to heat treatment. The invention further relates to a method of reducing leachables and/or extractables in prefilled syringes, said method comprising heat treating pre-fabricated syringes at a temperature of at least 40° C. before filling.

主权项

1. A method of reducing leachables and extractables in a pre-fabricated syringe having a needle fixed to a syringe body by use of a photo-curing adhesive, wherein the reduction of leachables and extractables is achieved by subjecting said prefabricated syringe to heat treatment, wherein the syringe is heated to a temperature of at least 40° C. to reduce the content of leachables and extractables in the syringe.