| 摘要 |
A gasket device is for use in a pre-filled syringe having a cylinder for containing liquid drug in sealing tightness. The liquid drug is pressurized by moving a plunger in the cylinder. The gasket device includes a gasket body, having resiliency, and movable toward the liquid drug with a front end of the plunger. A laminate layer is formed from PTFE (polytetrafluoroethylene), and disposed to cover a surface of the gasket body. The laminate layer includes a sealing portion, having a thickness Da, for sliding on an inner surface of the cylinder in sealing tightness. A liquid receiving portion has a thickness Db, for contacting the liquid drug in the cylinder. The thickness Da is from 10 microns to 40 microns. The thickness Db is from 20 microns to 50 microns. A ratio R1 of the thickness Db to the thickness Da is from 1.25 to 2.00. |
| 主权项 |
1. A gasket device for a pre-filled syringe including a cylinder for containing liquid drug in sealing tightness, said liquid drug being pressurized by moving a plunger in said cylinder, said gasket device comprising:
a gasket body, having resiliency, and movable toward said liquid drug with a front end of said plunger; a laminate layer, formed from fluorocarbon resin, and disposed to cover a surface of said gasket body; wherein said laminate layer includes: a sealing portion, having a first thickness, for sliding on an inner surface of said cylinder in sealing tightness; a liquid receiving portion, having a second thickness, for contacting said liquid drug in said cylinder; wherein said first thickness is equal to or more than 10 microns and equal to or less than 40 microns, said second thickness is equal to or more than 20 microns and equal to or less than 50 microns, and a ratio of said second thickness to said first thickness is equal to or more than 1.25 and equal to or less than 2.00. |
