Immediate release tablet formulations

摘要

The present invention provides an immediate release pharmaceutical formulation which includes a tablet or capsule formulation comprising metformin and the sodium dependent glucose transporter (SGLT2) inhibitor dapagliflozin or its propylene glycol hydrate. The present invention also provides methods of preparing the formulations and methods of treating diseases or disorders associated with SGLT2 activity employing these formulations.

主权项

1. A pharmaceutical formulation comprising: about 0.1-2% dapagliflozin or dapagliflozin (S) propylene glycol hydrate; about 55-85% metformin hydrochloride; about 1-15% hydroxypropyl cellulose; about 2-25% microcrystalline cellulose; about 1-12% sodium starch glycolate or about 3-10% hydroxypropyl cellulose, low substituted; about 0.25-5% magnesium stearate and optionally a coating; wherein the pharmaceutical formulation is an immediate release formulation and wherein the formulation is in the form of a tablet.