| 发明名称 | Glycan modified soluble receptors and binding protein and their use | ||
| 摘要 | An invention relates to a glycan-modified soluble receptor or binding protein of a cytokine, growth factor, lipoprotein or oxidized lipoprotein, modified to carry a terminal Gal, GlcNAc or GalNAc. | ||
| 申请公布号 | US8871723(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US200812598511 | 申请日期 | 2008.04.30 |
| 申请人 | Yeda Research and Development Co. Ltd. | 发明人 | Rubinstein Menachem;Werman Ariel;Alkahe Ben |
| 分类号 | A61K38/16;C07K14/00;C07K14/705;C07K14/71 | 主分类号 | A61K38/16 |
| 代理机构 | Marshall, Gerstein & Borun LLP | 代理人 | Marshall, Gerstein & Borun LLP |
| 主权项 | 1. A glycan-modified soluble low-density lipoprotein (LDL) receptor, modified to carry a terminal galactose (Gal), N-acetylglucosamine (GlcNAc) or N-acetylgalactosamine (GalNAc), wherein the glycan-modified soluble LDL receptor exhibits an increased circulatory clearance rate relative to an unmodified soluble LDL receptor. | ||
| 地址 | Rehovot IL | ||