| 发明名称 | Viral vectors and their use in therapeutic methods | ||
| 摘要 | The invention provides viral vectors (e.g., herpes viral vectors) and methods of using these vectors to treat disease. | ||
| 申请公布号 | US8871193(B2) | 申请公布日期 | 2014.10.28 |
| 申请号 | US201313924936 | 申请日期 | 2013.06.24 |
| 申请人 | Catherex, Inc.;The General Hospital Corporation;Georgetown University | 发明人 | Johnson Paul;Martuza Robert L.;Rabkin Samuel D.;Todo Tomoki |
| 分类号 | A61K39/245;A61K35/76;C12N15/86;A61K48/00;A61K39/00 | 主分类号 | A61K39/245 |
| 代理机构 | Clark & Elbing LLP | 代理人 | Clark & Elbing LLP |
| 主权项 | 1. A method of treating melanoma in a patient, said method comprising administering to a patient having melanoma a herpes simplex virus-1 comprising an inactivating mutation in the ICP47 locus of said virus that results in early expression of US11, and an inactivating mutation in the γ34.5 neurovirulence locus of said virus. | ||
| 地址 | Bala Cynwyd PA US | ||