Hydrophobic Molecule-Induced Branched Polymer Aggregates And Their Use

摘要

Symmetrically and asymmetrically branched homopolymers are modified at the surface level with functional groups that enable forming aggregates with water insoluble or poorly water soluble pharmaceutically active agents (PAA). The aggregates formed are specifically induced by interaction of PAA and homopolymer and are different from aggregates that are formed by the polymer alone in the absence of the PAA or by the PAA alone in the absence of the polymer. Such aggregates can be used to improve drug solubility, stability, delivery and efficacy.

主权项

1. An aggregate comprising
a) a branched homopolymer, wherein said homopolymer is modified with a surface group and wherein said surface modified branched homopolymer comprises symmetrically branched polymers, asymmetrically branched polymer or a combination thereof, and b) a water insoluble or poorly water soluble pharmaceutically active agent (PAA),wherein the size of said aggregate is different from the size of aggregates formed of said surface modified branched homopolymer alone.