EXENATIDE MICROSPHERE PREPARATION, PREPARATION METHOD AND APPLICATION THEREOF

摘要

The present invention provides an exenatide microsphere preparation, a preparation method thereof, and application thereof in preparing blood sugar decreasing and/or weight losing medicine. The microsphere preparation comprises exenatide and amino acid. Preferably, the preparation comprises 0.05%−10%w/w of exenatide, and 44%−98%w/w of amino acid and water, and optionally comprises an aliphatic polyester compound and a microsphere protective agent. A preparation method of the protective agent comprises: sequentially dissolving aliphatic polyester and an exenatide compound into an oil phase solvent to generate a uniform oil phase; dissolving amino acid and an emulsifying agent into water to form a uniform water phase; adding the oil phase to the water phase to form colostrums; thickening the colostrums; and volatilizing the oil phase.