摘要 |
<p>Disclosed is a method for producing a chiral tetrahydroquinoline derivative. In the present invention, the chiral tetrahydroquinoline derivative is produced through a 1,5-hydrogen transition reaction by adding a tetrahydrofuran solvent in alpha, beta-unsaturated ketone in which an aryl group having a dialkylamino group cyclized in an ortho position is substituted in a beta position under the presence of a chiral organic catalyst and an acid additive.</p> |