| 摘要 |
Genetically modified HBc polypeptides are provided. Virus-like particles (VLPs) are non-infectious, have repetitive surfaces that can display molecules with a high surface density, and have comparable cellular uptake and intracellular trafficking compared to natural virus. All of these functional attributes make them attractive as the assembly core for vaccines, diagnostics, and therapeutics. They can potentially serve as polyvalent scaffolds for the display of nucleic acids, proteins, and other chemical moieties. |
