1,2,3,4-TETRAHYDRO-6-SUBSTITUTED-4-ARYL(OR HETEROCYCLO)-3-SUBSTITUTED-2-THIOXO(OR OXO)-5-PYRIMIDINECARBOXYLIC ACIDS AND ESTERS

摘要

Cardiovascular activity is exhibited by compounds having the formula and pharmaceutically acceptable salts thereof wherein X is oxygen or sulfur; R1 is alkyl, cycloalkyl, alkenyl, alkynyl, aryl -(CH2)n-Y2, -(CH2)p-Y3 or halo substituted alkyl; R2 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, aryl, -(CH2)n-Y1, or halo substituted alkyl; R3 is hydrogen, alkyl, cycloalkyl, aryl, heterocyclo, -(CH2)n-Y2, -(CH2)p-Y3, or halo substituted alkyl; R4 is aryl or heterocyclo; Y1 is cycloalkyl, aryl, heterocyclo, hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, substituted amino, carbamoyl +TR Y2 is cycloalkyl, aryl, heterocyclo, carbamoyl, Y3 is hydroxyl, alkoxy, aryl-(CH2)m-O-, mercapto, alkylthio, aryl-(CH2)m-S-, amino, or substituted amino; m is 0 or an integer of 1 to 6; n is an integer of 1 to 6; and p is an integer of 2 to 6.