METHODS FOR DETERMINING TREATMENT RESPONSE IN PATIENTS INFECTED WITH HCV GENOTYPE 4

摘要

The present invention relates to a method for testing whether a patient infected with HCV genotype 4 could achieve a sustained virological response (SVR) to the combination of interferon-alpha and ribavirin comprising determining the patient's genotype for the single nucleotide polymorphism rs 12979860 wherein the presence of the better response allele C indicates a high chance to achieve a sustained virological response (SVR) and the presence of the allele T indicates a lower chance to achieve a sustained virological response (SVR).

主权项

1. A method for testing whether a patient infected with HCV genotype 4 could achieve a sustained virological response (SVR) to the combination of interferon-alpha and ribavirin comprising
determining the patient's genotype for the single nucleotide polymorphism (SNP) rs12979860 by i) isolating nucleic acid encoding the SNP rs12979860 from a sample from the subject; ii) amplifying the isolated nucleic acid by contacting the isolated nucleic acid with oligonucleotide primers specific for amplifying the SNP rs12979860; and iii) analyzing a nucleotide sequence of amplification products generated in said step of amplifying;wherein
if results obtained in said step of analyzing indicate that better response allele C is present at SNP rs12979860 of said nucleotide sequence, then concluding that the patient has a high chance to achieve a sustained virological response (SVR) and if results obtained in said step of analyzing indicate that worse response allele T is present at SNP rs12979860 of said nucleotide sequence, then concluding that the patient has a lower chance to achieve a sustained virological response (SVR).