SUBSTITUTED AMIDE COMPOUNDS

摘要

The present invention is directed at substituted amide compounds, pharmaceutical compositions containing such compounds and the use of such compounds to reduce plasma lipid levels, such as LDL-cholesterol and triglycerides and accordingly to treat diseases which are exacerbated by high levels of LDL-cholesterol and triglycerides, such as atherosclerosis and cardiovascular diseases, in mammals, including humans.

主权项

1. A compound having Formula I or a pharmaceutically acceptable salt thereof wherein R1 is pyrid-2-yl, isoquinolin-1-yl or 1H-pyrrolo[2,3-c]pyridin-7-yl; R1 is optionally mono- or di-substituted with chloro or (C1-C4)alkyl; X and Y are independently either N or C(H), provided that at least one of X or Y is C(H); R2 is H, fluoro, hydroxyl or methyl; R3 is wherein R6 and R8 are each independently H, methyl, halo or (C1-C4)alkyloxy, provided that only one of R6 and R8 is halo; wherein R10 and R11 are each independently H, (C1-C4)alkyl or (C3-C5)cycloalkyl; and wherein R7 is hydroxyl, (C1-C4)alkyloxy, (C1-C4)alkoxycarbonyloxy(C1-C4)alkyloxy, or (C1-C4)alkylcarbonyloxy(C1-C4)alkoxy.