发明名称 |
PROCESS FOR THE PREPARATION OF HIGHLY O-SULFATED, EPIMERIZED DERIVATIVES OF K5 POLYSACCHRIDE AND INTERMEDIATES THEREIN |
摘要 |
A new method is described for the oversulfation of epiK5-N-sulfate to obtain an epiK5-amine-O-oversulfate with very high sulfation degree which, by subsequent N-sulfation, provides new epiK5-N,O-oversulfate-derivatives with a sulfation degree of at least 4, basically free of activity on the coagulation parameters and useful in the cosmetic or pharmaceutical field. Also described are new low molecular weight epiK5-N-sulfates useful as intermediates in the preparation of the corresponding LMW-epiK5-N,O-oversulfate-derivatives. |
申请公布号 |
US2014316129(A1) |
申请公布日期 |
2014.10.23 |
申请号 |
US201414328271 |
申请日期 |
2014.07.10 |
申请人 |
GLYCORES 2000 S.R.L. |
发明人 |
ORESTE Pasqua Anna;ZOPPETTI Giorgio |
分类号 |
C08B37/00 |
主分类号 |
C08B37/00 |
代理机构 |
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代理人 |
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主权项 |
1. A process for the preparation of epiK5-amine-O-oversulfate-derivatives having a glucosamine 3-O-sulfate content of at least 40%, which comprises
(a) treating an epiK5-N-sulfate-derivative, in acidic form, with a tertiary or quaternary organic base, letting the reaction mixture to stand for a time period of 30-60 minutes at a pH of approximately 7 and isolating the corresponding organic base salt of said epiK5-N-sulfate; and (b) treating said tertiary amine or quaternary ammonium salt of said epiK5-N-sulfate-derivative with an O-sulfation agent in the conditions of O-oversulfation and isolating the epiK5-amine-O-oversulfate-derivative. |
地址 |
Milan IT |