| 发明名称 |
STABILIZED STAT3 DECOY OLIGONUCLEOTIDES AND USES THEREFORE |
| 摘要 |
The present invention is based, at least in part, on novel, unimolecular STAT3 oligonucleotide decoys exhibiting increased in vivo stability as compared to previously known decoys which are effective in inhibiting STAT3 when administered systemically. The invention is also based on pharmaceutical compositions comprising these unimolecular decoys, and methods for using these decoys in the treatment of cancer. |
| 申请公布号 |
US2014314816(A1) |
申请公布日期 |
2014.10.23 |
| 申请号 |
US201414245911 |
申请日期 |
2014.04.04 |
| 申请人 |
University of Pittsburgh - of the Commonwealth System of Higher Education |
发明人 |
Grandis Jennifer R.;Johnson Daniel;Ly Danith |
| 分类号 |
C07K14/47;A61K39/395;A61N5/00;A61K31/713 |
主分类号 |
C07K14/47 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A double-stranded STAT3 oligonucleotide decoy, wherein the decoy comprises an oligonucleotide that binds to STAT3 protein and is effective in inhibiting growth of a cancer in which STAT3 is activated when administered systemically to a subject, and wherein the decoy has a serum half-life of greater than about 1.5 hours. |
| 地址 |
Pittsburgh PA US |
