3,6-DIAZABICYCLO[3.1.1]HEPTAINES AS NEURONAL NICOTINIC ACETYCHOLINE RECEPTOR LIGANDS

摘要

The present invention relates to compounds that bind to and modulate the activity of neuronal nicotinic acetylcholine receptors, to processes for preparing these compounds, to pharmaceutical compositions containing these compounds, and to methods of using these compounds for treating a wide variety of conditions and disorders, including those associated with dysfunction of the central nervous system (CNS).

主权项

1. A compound of Formula I: wherein:
each m is identical and is 0 or 1;each n is identical and is 0 or 1;when each m is 0, then each n is 1;when each m is 1, then each n is 0; R1 is
—C(O)—R3A,—C(O)O—R3B, R2 is H; R3A is methyl, propyl, butyl, pentyl, hexyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, or heterocyclic; R3B is methyl, ethyl, propyl, n-butyl, isobutyl, sec-butyl, pentyl, hexyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, cycloalkynyl, aryl, heteroaryl, or heterocyclic; each R3A and R3B individually may be optionally substituted with one or more alkyl, alkenyl, alkynyl, aryl, aryloxy, amino, amido, heteroaryl, halogen, hydroxyl, alkoxy, cycloalkyl, cycloalkenyl, cycloalkynyl, heterocyclic, or alkylamido substituents; or a pharmaceutically acceptable salt thereof.