发明名称 |
PROCESS FOR THE MANUFACTURE OF NICORANDIL |
摘要 |
<p>Disclosed is a process for the synthesis of Nicorandil (1), 2-(nicotinamide)ethyl nitrate, starting from N-(2-hydroxyethyl)nicotinamide (15), using nitration with nitric acid in the presence of acetic anhydride Said synthesis method is particularly advantageous because it solves the safety problems involved in the use of nitric acid as nitrating agent, and allows a product with excellent yields and quality to be isolated.</p> |
申请公布号 |
EP2658839(B1) |
申请公布日期 |
2014.10.22 |
申请号 |
EP20110817220 |
申请日期 |
2011.12.28 |
申请人 |
PROCOS S.P.A. |
发明人 |
BAROZZA, ALESSANDRO;COLOMBO, MATTEO;ROLETTO, JACOPO;PAISSONI, PAOLO |
分类号 |
C07C201/02 |
主分类号 |
C07C201/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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