Methods of use for HSV-1 and HSV-2 vaccines

摘要

This invention provides methods of treating, suppressing, inhibiting, reducing an incidence, reducing the pathogenesis of, ameliorating the symptoms of, or ameliorating the secondary symptoms of a primary or recurring Herpes Simplex Virus (HSV) infection, or prolonging the latency to a relapse of an HSV infection, and disorders and symptoms associated with same and inducing an anti-HSV immune response in a subject comprising the step of contacting the subject with a composition comprising a mutant HSV strain comprising an inactivating mutation in a Us8 gene, followed by a second contacting with the composition.

主权项

1. A method of inducing an anti-Herpes Simplex Virus (HSV) immune response in a subject comprising the steps of (a) administering a composition comprising an attenuated HSV mutant to said subject, wherein said attenuated HSV mutant consists of a single inactivating mutation, wherein said inactivating mutation is a deletion of base pairs (bp) 369-1479 of SEQ ID NO: 7, which is a Us8 gene, and (b) administering a booster dose of said composition comprising said attenuated HSV mutant, wherein said attenuated HSV mutant has a defect in neuronal spread in the anterograde and retrograde directions, wherein said booster dose enhances the immune response induced by the initial administration of said attenuated HSV mutant.