| 发明名称 |
OLIGOMER-CORTICOSTEROID CONJUGATES |
| 摘要 |
The invention provides corticosteroids that are chemically modified by covalent attachment of a water-soluble oligomer. A compound of the invention, when administered by any of a number of administration routes, exhibits different properties compared to the properties of the corticosteroid not attached to the water-soluble oligomer. |
| 申请公布号 |
US2014309398(A1) |
申请公布日期 |
2014.10.16 |
| 申请号 |
US201414315998 |
申请日期 |
2014.06.26 |
| 申请人 |
NAKTAR THERAPEUTICS |
发明人 |
Zhang Wen;Riggs-Sauthier Jennifer;Harris J. Milton;Bentley Michael D. |
| 分类号 |
A61K31/573;A61K47/48 |
主分类号 |
A61K31/573 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A compound comprising a corticosteroid residue covalently attached via a releasable linkage to a poly(ethylene oxide), wherein the corticosteroid residue is a residue dexamethasone and the poly(ethylene oxide) is branched. |
| 地址 |
San Francisco CA US |
