COMPOSITIONS AND METHODS FOR THE DELIVERY OF THERAPEUTICS

摘要

In accordance with the instant invention, nanopartides/nanoformulations comprising at least one therapeutic agent and at least one surfactant linked to gp120 are provided. In a particular embodiment, the surfactant is an amphiphilic block copolymer, polysorbate, phospholipid, derivative thereof, or combination thereof. In a particular embodiment, the surfactant is an amphiphilic block copolymer. In a particular embodiment, the nanopartides/nanofonnulations further comprise other surfactants linked to at least one other targeting ligand. An individual nanopartide may comprise targeted and non-targeted surfactants. In a particular embodiment, the therapeutic agent is an antiviral, antiretroviral, or anti-HIV compound. In a particular embodiment, the surfactant is PLGA-PEG. Pharmaceutical compositions comprising at least nanoparticle of the instant invention and at least one pharmaceutically acceptable carrier are also provided.