| 主权项 |
1. A compound comprising formula I or prodrugs, esters, or salts thereof wherein, X is O or N; the dotted line is an optional bond to provide an absent, single, or double bond provided that if X is O and the bond between the X and the alpha carbon is a double bond, then R6 is absent; R1 and R2 are independently hydrogen or alkyl optionally substituted with one or more, the same or different, R7, or R1 and R2 form a 3-7 membered carbocyclic or heterocyclic ring optionally substituted with one or more, the same or different, R7; R3 and R4 are independently hydrogen, alkyl, or alkanoyl optionally substituted with one or more R7, or R1 and R3 and the atoms which they are attached form a 4-7 membered heterocyclic ring optionally substituted with one or more, the same or different, R7; R5 is a higher alkyl or other lipophilic moiety optionally substituted with one or more, the same or different, R7; R6 is hydrogen or alkyl wherein R6 is optionally substituted with one or more, the same or different, R7; R7 alkyl, halogen, nitro, cyano, hydroxy, amino, mercapto, formyl, carboxy, carbamoyl, alkoxy, alkanoyl, alkylthio, alkylamino, (alkyl)2amino, alkylsulfmyl, alkylsulfonyl, arylsulfonyl, carbocyclyl, aryl, or heterocyclyl, wherein R7 is optionally substituted with one or more, the same or different, R8; and R8 is halogen, nitro, cyano, hydroxy, trifluoromethoxy, trifluoromethyl, amino, formyl, carboxy, carbamoyl, mercapto, sulfamoyl, methyl, ethyl, methoxy, ethoxy, acetyl, acetoxy, methylamino, ethylamino, dimethylamino, diethylamino, N-methyl-N-ethylamino, acetylamino, N-methylcarbamoyl, N-ethylcarbamoyl, N,N-dimethylcarbamoyl, N,N-diethylcarbamoyl, N-methyl-N-ethylcarbamoyl, methylthio, ethylthio, methylsulfmyl, ethylsulfinyl, mesyl, ethylsulfonyl, methoxycarbonyl, ethoxycarbonyl, N-methylsulfamoyl, N-ethylsulfamoyl, N,N-dimethylsulfamoyl, N,N-diethylsulfamoyl, N-methyl-N-ethylsulfamoyl, carbocyclyl, aryl, or heterocyclyl. |
