| 发明名称 |
GENE THERAPY INDUCED PYROPTOSIS FOR THE TREATMENT OF TUMORS |
| 摘要 |
Described herein are compositions and methods for treating, inhibiting, preventing, reducing the severity of and/or reducing the progression of schwannoma, as well as any disease or physiological disease-state in which schwannoma plays a role. The compositions comprise an rAAV vector that includes a caspase-1 gene or a variant thereof and a Schwann cell specific promoter. |
| 申请公布号 |
US2014309288(A1) |
申请公布日期 |
2014.10.16 |
| 申请号 |
US201414169112 |
申请日期 |
2014.01.30 |
| 申请人 |
THE GENERAL HOSPITAL CORPORATION |
发明人 |
Brenner Gary J.;Breakefield Xandra O.;Fulci Giulia |
| 分类号 |
C12N15/86 |
主分类号 |
C12N15/86 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A recombinant adeno-associated virus (rAAV) vector comprising a caspase-1 gene or a variant thereof and a Schwann cell specific promoter. |
| 地址 |
Boston MA US |
