| 摘要 |
PROBLEM TO BE SOLVED: To provide a new mouse model of AD (Alzheimer's disease), which can duplicate a series of pathology of Aβaccumulation, neurofibril change and neurodegeneration in the human AD brain. SOLUTION: The nonhuman mammal of the animal model of the AD, which contains a chimera APP gene which can produce human Aβ, an animal or a part of the organism characterized by about 7 times or more (about 140 times or more in a homozygote) of the ratio of Aβ42/Aβ40 at 8 weeks-old compared to a corresponding wild animal, in another embodiment, the animal or a part of the organism is further characterized by the expression amount of APP not having significant difference compared to a corresponding wild animal. The method of screening a medicine for preventing/treating the Alzheimer's disease involves using the animal or the part of the organism. COPYRIGHT: (C)2012,JPO&INPIT |
