Compound reagents and method for synthesizing enantiomerically enriched amino acids

摘要

Described herein are compounds of formula (I), related compositions, and their use, for example in the formation of α-amino acids or a precursor thereof such as an α-aminonitrile.;

主权项

1. A compound or pharmaceutically acceptable salt thereof selected from the formula (I): wherein X is selected from O, S and NR5; R1a and R1b is optionally substituted aryl; R2 is hydrogen, optionally substituted alkyl; R3 is optionally substituted alkyl, optionally substituted aryl, optionally substituted cycloalkyl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted aralkyl, optionally substituted heteroaralkyl, or optionally substituted heterocyclylalkyl; R4 is optionally substituted alkyl, optionally substituted cycloalkyl, optionally substituted aryl, optionally substituted heteroaryl, optionally substituted heterocyclyl, optionally substituted heteroaralkyl, optionally substituted aralkyl or optionally substituted heterocyclylalkyl; R5 is hydrogen, alkyl, aryl, or arylalkyl.