发明名称 |
CONJUGATE-BASED ANTIFUNGAL AND ANTIBACTERIAL PRODRUGS. |
摘要 |
The invention provides conjugate-based antifungal or antibacterial prodrugs formed by coupling at least one antifungal agent or antibacterial agent with at least one linker and/or carrier. The prodrugs are of formula: (i) (AFA)m-X-(L)n; (ii) [(AFA)m'-X]p-L; (iii) AFA-[X-(L)n']q; or (iv) (AFA)m"-X, wherein: AFA is an antifungal agent or an antibacterial agent; L is a carrier; X is a linker; m ranges from 1 to 10; n ranges from 2 to 10; m' is 1 to 10; p is 1 to 10; n' is 1 to 10; and q is 1 to 10, provided that q' and n are not both 1; and m" is 1 to 10. The invention also provides nonaprticels comprising the conjugate-based prodrugs. Additonoally, the invention also provides non-conjugated antifungal and antibacterial agents in the form of nanoparticles. |
申请公布号 |
MX2013015434(A) |
申请公布日期 |
2014.10.14 |
申请号 |
MX20130015434 |
申请日期 |
2012.06.22 |
申请人 |
VYOME BIOSCIENCES PVT. LTD. |
发明人 |
ABHIJIT S. BAPAT;GAUTHAMI MAHESH;RAJESH S. GOKHALE;SAYALI S. SHAH;SHILADITYA SENGUPTA;SUDHANAND PRASAD;SUMANA GHOSH;SURESH R. CHAWRAI;NIDHI ARORA;D. SREEDHAR REDDY;MALLIKA MISHRA;KIRTI BAJAJ |
分类号 |
A61Q17/00;A61K8/37;A61K47/48;A61P17/10;A61P31/04;A61Q5/02 |
主分类号 |
A61Q17/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|