| 发明名称 |
METHODS FOR TREATING GRAFT VERSUS HOST DISEASE AND IMMUNE DISORDERS ASSOCIATED WITH REJECTION USING A SOLUBLE CTLA4 MOLECULE |
| 摘要 |
The present invention relates to the field of immune system diseases. In particular, the present invention relates to the use of a soluble CTLA4 mutant molecule, including L104EA29Ylg, for inhibiting T-cell function but not T-cell depletion by contacting B7-positive cells with the soluble CTLA4 mutant molecule, and thereby treating the immune system diseases. The soluble CTLA4 mutant molecules used all comprise a CTLA4 extracellular domain. The disorders treated include graft vs. host disease, immune disorders associated with graft transplantation rejection, chronic rejection, and tissue or cell allo- or xenographs. |
| 申请公布号 |
CA2630062(C) |
申请公布日期 |
2014.10.14 |
| 申请号 |
CA20012630062 |
申请日期 |
2001.07.02 |
| 申请人 |
BRISTOL-MYERS SQUIBB COMPANY |
发明人 |
COHEN, ROBERT;CARR, SUZETTE;HAGERTY, DAVID;PEACH, ROBERT J.;BECKER, JEAN-CLAUDE |
| 分类号 |
A61K38/00;A61K38/16;A61K31/4706;A61K31/519;A61K31/5355;A61K31/573;A61K38/13;A61K38/17;A61K39/395;A61K45/06;A61K47/48;A61P1/04;A61P1/16;A61P3/10;A61P7/00;A61P7/04;A61P7/06;A61P17/00;A61P17/02;A61P17/06;A61P19/02;A61P21/02;A61P21/04;A61P25/04;A61P25/28;A61P27/02;A61P29/00;A61P35/00;A61P35/02;A61P37/00;A61P37/02;A61P37/04;A61P37/06;A61P43/00;C07K;C07K14/705;C07K14/725;C12N15/09;C12P21/02;G01N33/53 |
主分类号 |
A61K38/00 |
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